American food and drug administration (FDA) approved the drug Leukovorin on Monday for use in the treatment of autism. President Donald Trump recently made a controversial announcement of promotion of unproven connection between autism and painkillers.
Some smaller studies have associated these problems with more serious symptoms of autism and indicate that leukovorin treatment can help improve verbal and social skills, as well as reduce irritability in these children.
Recent studies have shown that leukovorin can help alleviate certain symptoms of autism in specific children. However, field experts warned that a larger and stricter clinical evaluation were needed to draw fixed conclusions.
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Trump took a more aggressive attitude than his own food and drug management, which has issued cautious instructions that advised doctors to “consider minimizing” the use of acetaminophene during pregnancy because of inconclusive evidence of potential connection with autism.
Trump’s remarks coincided with the pressure of his administration to extend the approach to a potential, albeit unproven treatment of autism, as well as a wider commitment to increase disorder research.
Minister of Health Robert F. Kennedy Jr. At the beginning of this year he promised to determine the cause of autism by September. That brain experts saying that there is no single cause and it seems that rhetoric has ignored decades of scientific research of genetic and environmental factors that can play a role.
What is autism?
Autism is not a disease.
Up to 90 years, autism diagnoses were mostly limited to children with the most serious symptoms. According to the World Health Organization (WHO), autistic spectrum disorders (ASD) are a number of conditions marked with different levels of difficulty in social interaction and communication.
“They are also often associated with unusual behavior and patterns of activity, such as challenges in transition between tasks, intensive focus on specific details, and unique responses to sensory experiences,” The Who said.
The increase is not between deep cases; It is an increase in milder cases that were not historically considered autism, said expert Helen Tager-Flusberg of the University of Boston, as stated by AP.
Autism rates have increased for decades
Who noted that in 2021 it was estimated that about 1 out of 127 people around the world were affected by autism. This number is average and the prevalence rate can vary very much depending on the study. Some well -designed studies reported significantly higher rates.
In many countries with low and medium incomes, however, the real prevalence of autism remains unknown due to limited data.
Genetics plays a major role in autism, says an expert
Research has shown that genetics plays a major role in autism, and scientists identify hundreds of genes associated with the condition. These genes may be inherited, even if the parent shows no signs of autism, or they can arise from spontaneous mutations during the early brain development when fast dividing cells can make mistakes.
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Experts believe that different combinations of genetic and environmental factors can affect the way the brain of the fetus develops. They may include the age of the father, premature birth and certain medical conditions of mothers during pregnancy – such as fever, infection or diabetes, report, etc.
What about Tylenol?
Some research has proposed a potential connection between acetaminophene (a conventional over -the -counter pain reliever) that was during pregnancy and a higher risk of autism. However, many other studies did not find such a connection.
The coalition of scientists autism on Monday noted that the use of acetaminophene during pregnancy has not increased in recent decades, while the degree of autism continued to grow and other doubts about any direct connection.
At the same time, the Mother-Fetal Medicine Medicine Society warns that untreated fever during pregnancy-especially in the first trimester-Mohn to increase the risk of complications such as abortion, premature birth and other health problems.
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On Monday, the FDA issued instructions to doctors who recommend to limit the use of acetaminophene during pregnancy while acknowledging ongoing uncertainty. The agency said: “To be clear, while many studies reported a link between acetaminophene and autism, there was no causal relationship, and there are also studies that are contrary to this finding.”
The existing Tylenol label already advises pregnant women to consult a doctor before using the medicine.
Meanwhile, the company for maternal medicine claims that acetaminophene remains a safe and appropriate possibility for use during pregnancy.
What is the new treatment of autism possible?
According to the FDA Federal Register, leukovorin, a concentrated form of folic acid, which is usually recommended to pregnant women to support healthy fetal development.
What is leucovorin?
Leukovorin, also called folinic acid, is a type of folate, which is basic B vitamin (B9). The US food and drug administration approved leukovorin to act against the toxic effects of certain chemotherapeutic drugs such as methotrexate that disrupt the body’s ability to use folate, Reuters reported.
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Leucovorin is also used to increase the efficacy of other chemotherapeutic treatment procedures AK control of certain types of anemia. Can be administered by oral or intravenous injection.
According to the FDA website, more than six Leucovorin companies produce.
How does leucovorin differ?
Folate helps cells grow and divided. It also supports the immune system and helps produce healthy red blood cells. In the development of fruits, insufficient folate leads to a type of serious congenital defects called nerve tube defects.
Research from Suns Downstate Medical Center in Brooklyn, New York and other institutions suggests that up to 75% of children with autism may have genetic variations that affect their ability to process folate or have autoimmune disorders that prevent folate transport to the brain.
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“Women are already said to take folic acid before conception and during pregnancy, as it reduces the chances of certain congenital defects, advice that could also help reduce the risk of autism,” Taner-Flusberg said.
Leucovorin is sold for other health conditions and some families already use it in the hope of helping autism. But Taner-Flusberg warned that only a few small studies have been conducted so far.
“Is it something worth it? Yes, is it potentially in the individual’s sub -group,” she said. But there must be a large, very strict study to prove whether it really works.
Scientists and leading groups for advocacy of autism firmly revealed all concerns connecting vaccines with autism.
Childhood vaccines are subject to extensive testing to ensure safety, including studies on how and when more vaccines are administered together, and their safety is constantly monitored for years after approval.
“Undoubtedly the children will suffer,” said Dr. Paul Offita, pediatrician and vaccine expert in Children’s Hospital in Philadelphia.
Trump’s administration under pressure
Trump’s administration faces significant pressure from the Minister of Health Robert F. Kennedy Jr. Broad Make Health Again movement to deal with the growing number of autism diagnoses in the US in recent years.
According to experts, this increase is largely due to the widespread definition of autism-what now includes milder cases based on spectrum-improving diagnostic practices, etc.
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They emphasize that autism has no only cause and warns that current rhetoric overlooks decades of scientific research involved in genetic and environmental factors.
Children will undoubtedly suffer from Monday demands.
In addition to budget cuts in federal medical agencies, the CDC was internally divided into Kennedy’s controversial attitude. Last week, the key immunization panel-nuns, including several skeptics of vaccines mentioned by Kennedym-, presented their instructions on COVID-19 and other vaccinations.
(With Associated Press inputs, Reuters)
(Tagstotranslate) autism
