Picture only for representation purposes. | Photo Credit: Getty Images
Scientists from the Raman Research Institute (RRI) have developed an affordable electro-fluidal device that helps in preliminary screening of sickle cells (SCD).
According to RRI, an innovative, cost-effective electro-fluid microporaization device, quantifies the stiffness of the entire high-resolution cells and a high-performance manner, with a specific focus on Screening for SCDs.
“This technology has the potential to change preliminary diagnostic methods of blood disorders,” RRI said.
Gautam Soni, S. Kaushik and A. Mishr on the theme of soft condensed matter in RRI, Bengalur were developed by this device and R. Ross, S. Srivastava and CR Ross from St. Johns Medical College Hospital, Bengaluru helped test equipment on real world samples by comparing blood cells from patients with SCD from patients with donor.
High -resolution measurement
“This new technology performs measurements with high resolution changes in the physiology and rigidity of RBC cells and connects it with the basic state of the disease,” said Gautam Soni, head of the investigator.
RRI said that scientists were able to create a system that effectively distinguishes SCD and healthy RBC donors because of their own stiffness with high accuracy.
“They studied free -flight samples and tapered flight regime to measure the volume and stiffness of cells. They used Latrunculin and (an actin inhibitor that reduces cell stiffness), treated RBC to quantify the correlation between the micropór and cell stiffness first,” RRI said.
Using the above methodology, they have shown that their device allows fast alternative detection of mechanical abnormalities in RBC and can therefore act as a preliminary screening device for multiple blood states.
“The portability and cost efficiency of the device would make it an attractive opportunity for mass screening that would lead to early detection of SCDs in the country and urban areas of the country,” RRI said.
Cell stiffness
Furthermore, he said that the rigidity of the whole cells, which is a ubiquitous cell health parameter, can be applied outside Screening SCD, such as in areas of detection of tumor cells and veterinary disorders of blood.
“The principle of the device also has possible non -medical applications, for example in improving hydrogel materials used in drug provision systems,” RRI said.
Published – April 9, 2025 02:01 IS
