Scientists from the Indian Science Institute (IISC) in cooperation with the urban deep startup Theranautilus have created magnetic nanobotes that can penetrate deep into dentinal tubules, which are small tunnels in the teeth that lead to nerve endings.
Magnetic nanobots called Calbots can also consist of durable seals for worn enamel, offering permanent relief from sensitivity in one application.
Bioceramic cement
“Calbots use a brand new class of biceramic cement.
Dental hypersensitivity affects almost one of four people around the world and occurs when microscopic tubules in Dentin – a layer under enamel – are revealed due to erosion or gum recession.
According to IISC, these small tubules lead directly to the nerve endings, and therefore even a sip of cold water can cause sudden and sting pain.
Current solution
He added that most of the current solutions, such as toothpastes, offer only relief on the surface and need to be used regularly.
“However, Calbots varies. These 400 nanometer magnetic particles, loaded with a proprietary biococeramic formula based on calcium silicate, are guided by an external magnetic field deep into exposed tubules. “IISC said.
The research team used human teeth extracted for clinical reasons and created the conditions where Dentin was exposed.
On these samples, Calbots applied under the magnetic field for 20 minutes, during which the robots sealed dentinal tubules by creating deep stable plugs-the result confirmed by high-resolution display.
Animals
The team also proceeded to test animals in cooperation with scientists at the IISC Center for Neuroscience.
“It was a mouse to choose between cold and room temperature of water. Healthy mice preferred both the same. But the mice with induced dental water all avoided,” IISC said.
“After treating sensitive mice using our Calbot solution, they started drinking cold water again functioning as a magic. We saw 100% recovery of behavior. That was a great moment for us,” said Shanmukh Peddi, first author of the study and post-napkinland researcher at Nano and Engineering (CENENS), IISC and co-founder. co -founder and co -founder.
Published – August 11 2025 9:04
