New Delhi: The Indian Commission for Farmacopoeia (IPC), the body under the Ministry of Health, found that the commonly used antibiotic combination – sulfamethoxazole and trimethoprim – has shown serious side effects.
This remedy for a solid dose combination is a popular antimicrobial drug used to treat a wide range of bacterial infections such as pneumonia, bronchitis, skin infections, granuloma, urinary tract infections, etc.
The Commission noted that the drug shows a serious undesirable reaction in the form of leukopenia, a life -threatening condition that reduces the number of white blood cells.
The Analysis of Adverse Drug Reaction (ADRS) from the Pharmacovigilance Program of India (PVPI) Database Revealed That Suspected Drug-Sulfamethoxazole + Trimethoprim-Used for Indication (S) Pneumonia, infects in cystic fibrosis, meloidosis, listeriiiiSis, brucellosis, granuloma inguinale, otitis media, skin infections, pneumocystis carinii pneumonia – show an unfavorable drug reaction called leukopenia, ”IPC.
IPC asked healthcare professionals, patients and consumers to carefully monitor any undesirable drug reaction and report to the authorities if such a reaction occurred.
Medical experts have stated that doctors should be careful when prescribing this combination, especially in vulnerable patients, and regular blood tests can help capture any problems soon.
“Trimehoprime-sulfamethoxazole has been used for years to treat a number of common bacterial infections because it is effective and widely available. However, recent warnings from the Indian pharmacopoeia commission may have a harder link to leukopenia-pokles in white blood cells-it is serious side effects. RR Dutta, Hod, Internal Medicine, Paras Health Gurogram.
IPC monitors unfavorable drug reactions between the Indian population and recommends that the Standard Control Organization (CDSCO) organization (CDSCO) is adopted by appropriate regulatory decisions for safe use of drugs.
Previously, Mint reported that India’s general controller had ordered state/UT to maintain careful supervision of the sale of unapproved antibiotic combinations and ensure that these cocktail drugs could not find their way to the market. It is planned to stop the wrong antibiotics.
Last year, IPC 10 issued alerts of drug safety.
Antimicrobial resistance (AMR), often due to excessive use or improper use of drugs, has proven to be a serious and growing threat to public health around the world, with approximately 600,000 lives in India due to these AMR infections.
Questions sent by spokesperson of the Ministry of Health remained unanswered.
According to Crisil Market Intelligence and Analytics, the market size of the anti -infectious segment in India £251.3 billion for FY24. These include antibiotics, antivirals and antifungals.
(Tagstotranslate) leukopenia
